Stefan Arver, MD, PhD

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Education

• 1977 - BA - Pre Clin Med School, Karolinska Institutet (Stockholm, Sweden)
• 1981 - MD - Medicine, Karolinska Institutet (Stockholm, Sweden)
• 1982 - PhD - Physiology, Karolinska Institutet (Stockholm, Sweden)
• 1982-1984 - Internship, Karolinska Institutet (Stockholm, Sweden)
• 1991 - Specialist Clin Endocrinology, Karolinska Institutet (Stockholm, Sweden)
• 1986 - Associate Professor, Karolinska Institutet (Stockholm, Sweden)
• 1996-1997 - Guest Professor, Reproductive Endocrinology, UCLA , Dept Endocrinology

Research positions

• 1976-1980 - Research fellow Dept of Physiology, Karolinska Institute
• 1980-1983 - Lecturer in Physiology, Karolinska Institute 
• 1987 -1989 - Research position Swedish MRC (transfer from pre-clinical to clinical research.
• 1986-present - Associate professor Karolinska Institute 
• 1984-1986 - Clinical lecturer in Internal Medicine 
• 1988 – 1992 - Clinical lecturer in Endocrinology 
• 1996-1998 - Guest Professor UCLA School of Medicine, Department of Medicine 

Clinical positions

• 1982-1984 - Internship Karolinska Institute at Danderyds Hospital, Dept of Surgery, Psychiatry and Internal Medicine 
• 1984-198 - Residency - Internal Medicine, Dept of Internal Medicine, Danderyds Hospital.
• 1987-1989 - Fellowship - Department of Endocrinology, Karolinska Hospital. 
• 1990 - Specialist in Endocrinology 
• 1990-199 - Senior Physician Dept Endocrinology 
• 1988 - 1993 - In charge Andrology section Department of Endocrinology, Karolinska Hospital 
• 1988-1993 - Director - Consultant Dept of Urology, Karolinska Hospital 
• 1992-1999 - Chief physician - Andrology Unit, Karolinska Hospital 
• 2000-present - Director - Andrology Center, Karolinska Hospital 

Selected peer-reviewed publications

• Dobs AS, Bachorik PS, Arver S, Meikle AW, Sanders SW, Caramelli KE, Mazer NA. Interrelationships among Lipoprotein Levels, Sex Hormones, Anthropometric Parameters, and Age in Hypogonadal Men Treated for 1 Year with a Permeation-Enhanced Testosterone Transdermal System. J Clin Endocrinol Metab. 2001 Mar;86(3):1026-33.
• Osterlund C, Segersteen E, Arver S, Pousette A. Low number of Y-chromosome deletions in infertile azoospermic men at a Swedish andrology centre. Int J Androl. 2000 Aug;23(4):225-9.
• Arver S, Jacobsson H, Cedermark B, Hamberger B, Lundell G, Grimelius L, Brismar K. Malignant human renin producing paraganglionoma-localization with 123I-MIBG and treatment with 131I-MIBG. Clin Endocrinol (Oxf). 1999 Nov;51(5):631-5.
• Rapado A, Hawkins F, Sobrinho L, Diaz-Curiel M, Galvao-Telles A, Arver S, Melo Gomes J, Mazer N, Garcia e Costa J, Horcajada C, Lopez-Gavilanes E, Mascarenhas M, Papapietro K, Lopez Alvarez MB, Pereira MC, Martinez G, Valverde I, Garcia JJ, Carballal JJ, Garcia I. Bone mineral density and androgen levels in elderly males. Calcif Tissue Int. 1999 Dec;65(6):417-21.
• Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA. Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endocrinol Metab. 1999 Oct;84(10):3469-78.
• Arver S, Sinha-Hikim I, Beall G, Guerrero M, Shen R, Bhasin S. Serum dihydrotestosterone and testosterone concentrations in human immunodeficiency virus-infected men with and without weight loss. J Androl. 1999 Sep-Oct;20(5):611-8. Mårin P, Arver S Androgens and abdominal obesity. Baillieres Clin Endocrinol Metab 1998 Oct;12(3):441-51
• Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14938-43
• Giwercman YL, Xu C, Arver S, Pousette A, Reneland R No association between the androgen receptor gene CAG repeat and impaired sperm production in Swedish men. Clin Genet 1998 Nov;54(5):435-6
• Bhasin S, Storer TW, Asbel-Sethi N, Kilbourne A, Hays R, Sinha-Hikim I, Shen R, Arver S, Beall G. Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab 1998 Sep;83(9):3155-62
• Meikle AW, Arver S Sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998 Sep 3;339(10):700-1; discussion 701-2
• Sinha-Hikim I, Arver S, Beall G, Shen R, Guerrero M, Sattler F, Shikuma C, Nelson JC, Landgren BM, Mazer NA, Bhasin S The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 1998 Apr;83(4):1312-8
• Arver S, Dobs AS, Meikle AW, Caramelli KE, Rajaram L, Sanders SW, Mazer NA Long-term efficacy and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men. Clin Endocrinol (Oxf) 1997 Dec;47(6):727-37
• Helgason AR, Arver S, Adolfsson J, Dickman P, Granath F, Steineck G 'Potency': the validation of information from a self-administered questionnaire using objective measurements of night-time erections and test-retest reliability. Br J Urol 1998 Jan;81(1):135-41
• Nordgren A, Arver S, Kvist U, Carter N, Blennow E Trisomy 5q12-->q13.3 in a patient with add(13q): characterization of an interchromosomal insertion by forward and reverse chromosome painting. Am J Med Genet 1997 Dec 19;73(3):351-5
• Pousette A, Leijonhufvud P, Arver S, Kvist U, Pelttari J, Hoog C Presence of synaptonemal complex protein 1 transversal filament-like protein in human primary spermatocytes. Hum Reprod 1997 Nov;12(11):2414-7 
• Kastury K, Taylor WE, Shen R, Arver S, Gutierrez M, Fisher CE, Coucke PJ, Van Hauwe P, Van Camp G, Bhasin S Complementary deoxyribonucleic acid cloning and characterization of a putative human axonemal dynein light chain gene. J Clin Endocrinol Metab 1997 Sep;82(9):3047-53
• Helgason AR, Adolfsson J, Dickman P, Arver S, Fredrikson M, Steineck G Factors associated with waning sexual function among elderly men and prostate cancer patients. J Urol 1997 Jul;158(1):155-9
• Prostate size in hypogonadal men treated with a nonscrotal permeation-enhanced testosterone transdermal system. Meikle AW, Arver S, Dobs AS, Adolfsson J, Sanders SW, Middleton RG, Stephenson RA, Hoover DR, Rajaram L, Mazer NA Urology 1997 Feb;49(2):191-6
• Helgason AR, Adolfsson J, Dickman P, Arver S, Fredrikson M, Gothberg M, Steineck G Sexual desire, erection, orgasm and ejaculatory functions and their importance to elderly Swedish men: a population-based study.
  Age Ageing 1996 Jul;25(4):285-91 
• Helgason AR, Adolfsson J, Dickman P, Fredrikson M, Arver S, Steineck G Waning sexual function--the most important disease-specific distress for patients with prostate cancer. Br J Cancer 1996 Jun;73(11):1417-21
• Arver S, Dobs AS, Meikle AW, Allen RP, Sanders SW, Mazer NA Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J Urol 1996 May;155(5):1604-8
• Meikle AW, Arver S, Dobs AS, Sanders SW, Rajaram L, Mazer NA Pharmacokinetics and metabolism of a permeation-enhanced testosterone transdermal system in hypogonadal men: influence of application site- -a clinical research center study. J Clin Endocrinol Metab 1996 May;81(5):1832-40

Research support

• Pharmacia Phase II Dose finding study Potassium channel opener for treatment of erectile dysfunction, a pharmacokinetic, pharmacodynamic study in men with severe erectile dysfunction PI
• Abbot International (Chicago) Pharmacokinetic study (phase II) with a transmucosal testosterone delivery system PI 
• TheraTech, Inc (Salt Lake City) Pharmacokinetics and pharmacodynamics of a non-scrotal transdermal testosterone delivery system PI, Phase II through Phase III Clinical studies
• Pfizer Inc Efficacy and safety study of Sildenafil for the treatment of male erectile dysfunction – dose titration PI
• Swedish Medical Research Council, Regulation of Spermatogenesis Transition from pre-clinical to clinical research and guest professor support PI and personal grants
• Swedish Cancer Foundation Molecular and androgenic pathways involved in prostate cancer